Anthrax Protective Antigen antibody (Internal Region)

Catalog No. ABIN7794901

This anti-Anthrax Protective Antigen antibody is a Rabbit Polyclonal antibody detecting Anthrax Protective Antigen in . Suitable for Bacillus anthracis.

Quick Overview for Anthrax Protective Antigen antibody (Internal Region) (ABIN7794901)

Target: Anthrax Protective Antigen (PA)

Reactivity: Bacillus anthracis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Anthrax Protective Antigen antibody is un-conjugated

Application: Please inquire

Product Details anti-Anthrax Protective Antigen Antibody

Binding Specificity: Internal Region

Purpose: Anti-Anthrax Protective Antigen (Intermediate Domain)

Specificity: Rabbit Anti-Anthrax Protective Antigen (Anthrax PA) recognizes an epitope in the intermediate domain of Anthrax PA. This polyclonal antibody was purified using affinity chromatography. Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin protective antigen (PA), lethal factor (LF), and edema factor (EF)1,2. PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2),4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.

Application Details

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/mL

Buffer: This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02 % sodium azide as a preservative.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Target Details for Anthrax Protective Antigen

Target: Anthrax Protective Antigen (PA)

Alternative Name: Anthrax Protective Antigen

Background: Anthrax Protective Antigen,