Recombinant TFEB antibody (C-Term)

Catalog No. ABIN7795623

The Rabbit Monoclonal anti-TFEB antibody has been validated for WB, FACS and IP. It is suitable to detect TFEB in samples from Human and Mouse.

Quick Overview for Recombinant TFEB antibody (C-Term) (ABIN7795623)

Target: TFEB (Transcription Factor EB (TFEB))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TFEB antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: BLR070G

Product Details anti-TFEB Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-TFEB Recombinant Monoclonal Antibody [BLR070G] - BSA-Free

Purification: Purified

Immunogen: Between 426 and C-terminus

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1000 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.09 % Sodium Azide, BSA-Free

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for TFEB

Target: TFEB (Transcription Factor EB (TFEB))

Alternative Name: TFEB

Background: Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P19484].

Gene ID: 7942

UniProt: P19484