GM1123 antibody (PE-Cy5)

Catalog No. ABIN739587

This anti-GM1123 antibody is a Rabbit Polyclonal antibody detecting GM1123 in WB and FACS. Suitable for Human, Mouse, Rat, Cow, Dog and Pig.

Quick Overview for GM1123 antibody (PE-Cy5) (ABIN739587)

Target: GM1123 (Predicted Gene 1123 (GM1123))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GM1123 antibody is conjugated to PE-Cy5

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-GM1123 Antibody (PE-Cy5)

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Coxsackie Adenovirus Receptor

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GM1123

Target: GM1123 (Predicted Gene 1123 (GM1123))

Alternative Name: Coxsackie Adenovirus Receptor

Background:

Synonyms: CAR, HCAR, CAR4/6, Coxsackievirus and adenovirus receptor, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR, CXADR

Background: Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Molecular Weight: 40kDa

Gene ID: 1525

UniProt: P78310