PVRL4 antibody

Catalog No. ABIN7822915

This anti-PVRL4 antibody is a Mouse Monoclonal antibody detecting PVRL4 in IHC. Suitable for Human.

Quick Overview for PVRL4 antibody (ABIN7822915)

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PVRL4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: NECT4-7271

Product Details anti-PVRL4 Antibody

Purpose: PVRL4 Antibody / Nectin-4

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1-200 from the human protein was used as the immunogen for the PVRL4 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Immunohistochemistry (FFPE): 1-2ug/ml

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Preservative: Sodium azide

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: Aliquot the PVRL4 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Target Details for PVRL4

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Alternative Name: Poliovirus Receptor-Related 4

Background: Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization