DLG2 antibody (pTyr340) (HRP)

Catalog No. ABIN744992

The Rabbit Polyclonal anti-DLG2 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect DLG2 in samples from Rat and Mouse.

Quick Overview for DLG2 antibody (pTyr340) (HRP) (ABIN744992)

Target: DLG2 (Discs, Large Homolog 2 (DLG2))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLG2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-DLG2 Antibody (HRP)

Binding Specificity: pTyr340

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human PSD93 around the phosphorylation site of Tyr340

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DLG2

Target: DLG2 (Discs, Large Homolog 2 (DLG2))

Alternative Name: PSD93

Background:

Synonyms: Channel associated protein of synapse 110, Channel associated protein of synapses 110kD, Channel-associated protein of synapse-110, Chapsyn 110, Chapsyn-110, Chapsyn110, discs large homolog 2, Discs, large homolog 2 Drosophila, Disks large homolog 2, DKFZp781D1854, DKFZp781E0954, Dlg 2, dlg2, DLG2_HUMAN, Dlgh 2, Dlgh2, FLJ37266, Gm1197, MGC131811, Postsynaptic density protein PSD 93, Postsynaptic density protein PSD-93, Postsynaptic density protein PSD93, PSD 93, PSD93.

Background: PSD 93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD 93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD 93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD 93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

Gene ID: 1740