CACNA1E antibody (AA 1265-1360) (Biotin)

Catalog No. ABIN751350

Product Details anti-CACNA1E Antibody (Biotin)

Target: CACNA1E (Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E))

Binding Specificity: AA 1265-1360

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1E antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cav23

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CACNA1E

Target: CACNA1E (Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E))

Alternative Name: CACH6/Cav2.3 (CACNA1E Products)

Background:

Synonyms: BII, Brain calcium channel II, CAC 1E, CAC1E, CACH 6, CACH6, CACNA1E, Cacnl1 a6, CACNL1A6, Calcium channel, L type, alpha 1 polypeptide, isoform 6, calcium channel, R type, Cav 2.3, Cchra 1, Cchra1, Voltage dependent R type calcium channel subunit alpha 1E, Voltage gated calcium channel subunit alpha Cav2.3.

Background: Calcium channels mediate the influx of calcium ions into the cell following membrane polarisation. R-type calcium channels such as Cav2.3 belong to the "high voltage-activated" group and are blocked by nickel. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Each of these proteins exists as multiple isoforms, either encoded by different genes or arising from alternative splicing of transcripts. Cav2.3 is an alpha-1 subunit and has 24 transmembrane segments, which form the pore through which ions pass into the cell. Calcium channels containing the Cav2.3 subunit may be involved in the modulation of firing patterns of neurons, which is important for information processing.

Gene ID: 777

Pathways: Carbohydrate Homeostasis