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STXBP1 antibody (AA 11-110) (Cy5.5)

This anti-STXBP1 antibody is a Rabbit Polyclonal antibody detecting STXBP1 in WB, IF (cc) and IF (p). Suitable for Rat.
Catalog No. ABIN751668

Quick Overview for STXBP1 antibody (AA 11-110) (Cy5.5) (ABIN751668)

Target

See all STXBP1 Antibodies
STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reactivity

  • 53
  • 42
  • 34
  • 7
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Rat

Host

  • 61
  • 6
  • 2
Rabbit

Clonality

  • 61
  • 8
Polyclonal

Conjugate

  • 43
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
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  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
This STXBP1 antibody is conjugated to Cy5.5

Application

  • 53
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  • 12
  • 12
  • 7
  • 7
  • 5
  • 2
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  • 1
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  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

    • 14
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    • 1
    • 1
    • 1
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    • 1
    • 1
    AA 11-110

    Cross-Reactivity

    Rat

    Predicted Reactivity

    Human,Mouse,Dog,Pig,Horse,Chicken

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Munc18

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

    Alternative Name

    STXBP1/Munc18

    Background

    Synonyms: Munc 18 1, Munc 18a, NSec1, p67, Rb sec1, STXBP1, Syntaxin binding protein 1, Unc 18 homolog, Unc 18A, Unc18 1, STXB1_HUMAN, Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67.

    Background: Munc18 may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP binding proteins. It is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Munc18 can interact with syntaxins 1, 2, and 3 but not syntaxin 4. It may play a role in determining the specificity of intracellular fusion reactions.Mutations in Munc18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Two Munc18 isoforms have recently been identified. Munc18-1 has been shown to be primarily expressed in brain, while Munc18-2 is expressed in most tissues.

    Gene ID

    6812

    UniProt

    P61764

    Pathways

    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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