STRAP antibody (AA 51-150) (Biotin)

Catalog No. ABIN755319

This anti-STRAP antibody is a Rabbit Polyclonal antibody detecting STRAP in WB, ELISA, IHC (p) and IHC (fro). Suitable for Human.

Quick Overview for STRAP antibody (AA 51-150) (Biotin) (ABIN755319)

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRAP antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-STRAP Antibody (Biotin)

Binding Specificity: AA 51-150

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Unrip

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for STRAP

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Alternative Name: Unrip

Background:

Synonyms: MAP activator with WD repeats, MAWD, PTWD, serine/threonine kinase receptor associated protein, STRAP, UNR-interacting protein, UNRIP, WD 40 repeat protein PT WD, STRAP_HUMAN.

Background: Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation.It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.

Gene ID: 11171