MFSD2A antibody (AA 331-430)

Catalog No. ABIN762026

The Rabbit Polyclonal anti-MFSD2A antibody has been validated for WB, ELISA, FACS, IF (cc), IF (p), IHC (p) and IHC (fro). It is suitable to detect MFSD2A in samples from Human, Mouse and Rat. There are 2+ publications available.

Quick Overview for MFSD2A antibody (AA 331-430) (ABIN762026)

Target: MFSD2A (Major Facilitator Superfamily Domain Containing 2A (MFSD2A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MFSD2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MFSD2A Antibody

Binding Specificity: AA 331-430

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MFSD2A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-MFSD2A antibody (ABIN762026)

Díaz-Carballo, Klein, Acikelli, Wilk, Saka, Jastrow, Wennemuth, Dammann, Giger-Pabst, Khosrawipour, Rassow, Nienen, Strumberg: "Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells." in: Oncotarget, Vol. 8, Issue 56, pp. 95945-95964, (2017) (PubMed).

Target Details for MFSD2A

Target: MFSD2A (Major Facilitator Superfamily Domain Containing 2A (MFSD2A))

Alternative Name: Mfsd2a

Background:

Synonyms: NLS1, MFSD2, Sodium-dependent lysophosphatidylcholine symporter 1, Sodium-dependent LPC symporter 1, Major facilitator superfamily domain-containing protein 2A, MFSD2A, HMFN0656, PP9177, UNQ300/PRO341

Background: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732).

Gene ID: 84879

UniProt: Q8NA29