NET1 antibody (AA 331-430) (HRP)

Catalog No. ABIN763415

The Rabbit Polyclonal anti-NET1 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect NET1 in samples from Mouse.

Quick Overview for NET1 antibody (AA 331-430) (HRP) (ABIN763415)

Target: NET1 (Neuroepithelial Cell Transforming 1 (NET1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NET1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-NET1 Antibody (HRP)

Binding Specificity: AA 331-430

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NET1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NET1

Target: NET1 (Neuroepithelial Cell Transforming 1 (NET1))

Alternative Name: NET1

Background:

Synonyms: mNET1, ARHGEF8, GLYT2, Guanine nucleotide regulatory protein oncogene, NET1A, Neuroepithelial cell transforming gene 1, p65 Net1 proto oncogene, Rho guanine nucleotide exchange factor GEF 8, ARHG8_HUMAN.

Background: This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene ID: 10276

Pathways: Neurotrophin Signaling Pathway