SIK2 antibody (Center)

Catalog No. ABIN783466

This Rabbit Polyclonal antibody specifically detects SIK2 in WB and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SIK2 antibody (Center) (ABIN783466)

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SIK2 Antibody

Binding Specificity: Center

Specificity: This antibody detects SIK2 at Center. SIK2 antibody is predicted to not cross-react with other SIK protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the center of human SIK2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for SIK2

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Alternative Name: SIK2

Background: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1?alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.Synonyms: QIK, Qin-induced kinase, SIK-2, SNF1LK2, Salt-inducible protein kinase 2, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SNF1-like kinase 2

Gene ID: 23235

NCBI Accession: NP_056006

UniProt: Q9H0K1