Secernin 1 antibody (C-Term)

Catalog No. ABIN783653

The Rabbit Polyclonal anti-Secernin 1 antibody has been validated for WB, IF and EIA. It is suitable to detect Secernin 1 in samples from Human, Mouse and Rat.

Quick Overview for Secernin 1 antibody (C-Term) (ABIN783653)

Target: Secernin 1 (SCRN1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Secernin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-Secernin 1 Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Immunogen: 20 amino acid peptide near the carboxy terminus of human SCRN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for Secernin 1

Target: Secernin 1 (SCRN1)

Alternative Name: Secernin-1 (SCRN1)

Background: SCRN1 was first identified as a cytosolic protein that is involved in the regulation of exocytosis from peritoneal mast cells. More recent studies have shown that SCRN1 expression is upregulated in gastric cancer cell lines and may possess epitopes that could function as tumor-associated antigens, potentially providing targets for cancer vaccines in the treatment of gastric cancers. Another report indicates that decreased expression of SCRN1 via RNAi expression resulted in significantly lower rates of cell growth in colorectal cancer cell lines, and increased SCRN1 expression in patients with colorectal cancer correlated with poor prognosis, suggesting that SCRN1 may also be involved in the regulation of cell growth and might be useful as a prognostic tool.Synonyms: KIAA0193

Gene ID: 9805

NCBI Accession: NP_001138985

UniProt: Q12765