BANP antibody (Center)

Catalog No. ABIN783725

The Rabbit Polyclonal anti-BANP antibody has been validated for WB and EIA. It is suitable to detect BANP in samples from Human, Mouse and Rat.

Quick Overview for BANP antibody (Center) (ABIN783725)

Target: BANP (Protein BANP (BANP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BANP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-BANP Antibody

Binding Specificity: Center

Specificity: This antibody detects BANP / SMAR1 at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the center of human BANP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Antibody is supplied in PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for BANP

Target: BANP (Protein BANP (BANP))

Alternative Name: BANP / SMAR1

Background: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-b signaling. Furthermore, BANP can modulate NF-kB transactivation and can inhibit tumorigenesis by regulating NF-kB target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.Synonyms: BEN domain-containing protein 1, BEND1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein

Gene ID: 54971

NCBI Accession: NP_001167010

UniProt: Q8N9N5