Neuropilin 1 antibody

Catalog No. ABIN866080

This Mouse Monoclonal antibody specifically detects Neuropilin 1 in WB and ICC. It exhibits reactivity toward Mouse.

Quick Overview for Neuropilin 1 antibody (ABIN866080)

Target: Neuropilin 1 (NRP1)

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuropilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Clone: 10-D9

Product Details anti-Neuropilin 1 Antibody

Specificity: This antibody is produced by immunizing mouse with recombinant protein Neuropilin-1.

Cross-Reactivity: Mouse (Murine)

Characteristics: Positive Control: Recombinant protein. Cellular Localization: Cell membrane, secretory protein

Isotype: IgM

Application Details

Application Notes: WB 1:1,000~1:2,000. ICC 1:100~1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.17mg/ml

Buffer: 1xTBS (pH7.4), 0.5% BSA, 25% Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Neuropilin 1

Target: Neuropilin 1 (NRP1)

Alternative Name: Neuropilin-1

Background: Neuropilin-1 is a single-pass type I membrane protein, which has two isoforms. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. The soluble isoform 2 binds VEGF-165 (vascular endothelial growth factor165) and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. Its expression has an averse effect on blood vessel number and integrity.

Molecular Weight: 47kDa

UniProt: P97333

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals