Corin antibody (AA 165-245)

Catalog No. ABIN872360

The Rabbit Polyclonal anti-Corin antibody has been validated for ELISA and IF (cc). It is suitable to detect Corin in samples from Human, Rat and Sheep. There are 2+ publications available.

Quick Overview for Corin antibody (AA 165-245) (ABIN872360)

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Reactivity: Human, Rat, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Corin antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-Corin Antibody

Binding Specificity: AA 165-245

Cross-Reactivity: Human, Rat, Sheep

Predicted Reactivity: Mouse,Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Corin

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Corin antibody (ABIN872360)

Miyazaki, Nishizawa, Kambayashi, Ito, Noda, Terasawa, Kato, Miyamura, Shiogama, Sekiya, Kurahashi, Fujii: "Increased levels of soluble corin in pre-eclampsia and fetal growth restriction." in: Placenta, Vol. 48, pp. 20-25, (2017) (PubMed).

Sari, Rufaut, Jones, Sinclair: "Characterization of Ovine Dermal Papilla Cell Aggregation." in: International journal of trichology, Vol. 8, Issue 3, pp. 121-9, (2016) (PubMed).

Target Details for Corin

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Alternative Name: Corin

Background:

Synonyms: CRN, ATC2, Lrp4, PEE5, TMPRSS10, Atrial natriuretic peptide-converting enzyme, Corin, Heart-specific serine proteinase ATC2, Pro-ANP-converting enzyme, Transmembrane protease serine 10

Background: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared to isoform 1.

Gene ID: 10699

UniProt: Q9Y5Q5

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones