RBPJ antibody (Recombination Signal Binding Protein For Immunoglobulin kappa J Region) (AA 100-150)

Details for Product anti-RBPJ Antibody No. ABIN872972
Antigen
Epitope
AA 100-150
14
10
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4
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
105
42
36
6
5
3
3
3
3
2
1
1
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1
Host
Rabbit
90
10
4
2
Clonality
Polyclonal
Conjugate
This RBPJ antibody is un-conjugated
6
4
4
3
3
3
3
3
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2
2
2
1
1
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1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
77
37
37
13
12
8
6
5
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Options
Immunogen KLH conjugated synthetic peptide derived from human RBPJK
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name Rbpjk (RBPJ Antibody Abstract)
Background

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.

Subcellular location: Nucleus

Synonyms: SUH, csl, AOS3, CBF1, KBF2, RBP-J, RBPJK, IGKJRB, RBPSUH, IGKJRB1, Recombining binding protein suppressor of hairless, CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, Renal carcinoma antigen NY-REN-30, RBPJ

Gene ID 3516
UniProt Q06330
Pathways Notch Signaling, Stem Cell Maintenance, Smooth Muscle Cell Migration
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) (AA 100-150) antibody (ABIN872972) Lane 1: mouse embryo lysates Lane 2: human colon carcinoma lysates probed with Anti R...
Image no. 2 for anti-Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) (AA 100-150) antibody (ABIN872972) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti RBPJK ...
Image no. 3 for anti-Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) (AA 100-150) antibody (ABIN872972) Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti RBPJK/...