CLK2 antibody (AA 401-499) (Cy3)

Catalog No. ABIN891287

The Rabbit Polyclonal anti-CLK2 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect CLK2 in samples from Human, Mouse and Rat.

Quick Overview for CLK2 antibody (AA 401-499) (Cy3) (ABIN891287)

Target: CLK2 (CDC-Like Kinase 2 (CLK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLK2 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CLK2 Antibody (Cy3)

Binding Specificity: AA 401-499

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLK2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CLK2

Target: CLK2 (CDC-Like Kinase 2 (CLK2))

Alternative Name: CLK2

Background:

Synonyms: CDC like kinase 2, CLK 2, CLK kinase, Clk2 Scamp3, Dual specicity protein kinase CLK2, hCLK 2, hCLK2, MGC61500, Tu52, CLK2_HUMAN.

Background: CDC-like kinase 2 (CLK2) belongs to a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases), which have been shown to phosphorylate serine- and arginine-rich (SR) proteins of the spliceosomal complex, and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the CLK2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.

Gene ID: 1196

Pathways: Regulation of Carbohydrate Metabolic Process