COMMD1 antibody (AA 95-190) (Biotin)

Catalog No. ABIN891771

This anti-COMMD1 antibody is a Rabbit Polyclonal antibody detecting COMMD1 in WB, ELISA, IHC (p) and IHC (fro). Suitable for Mouse.

Quick Overview for COMMD1 antibody (AA 95-190) (Biotin) (ABIN891771)

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMMD1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-COMMD1 Antibody (Biotin)

Binding Specificity: AA 95-190

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COMMD1/MURR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for COMMD1

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Alternative Name: COMMD1

Background:

Synonyms: C2orf5, COMD1, COMD1_HUMAN, COMM domain-containing protein 1, COMMD1, copper metabolism domain containing 1, MGC27155, MURR1, Protein Murr1.

Background: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.Tissue specificity:Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.

Gene ID: 150684

Pathways: Transition Metal Ion Homeostasis