Corin antibody (AA 165-245) (HRP)

Catalog No. ABIN891970

This Rabbit Polyclonal antibody specifically detects Corin in ELISA. It exhibits reactivity toward Human, Rat and Sheep.

Quick Overview for Corin antibody (AA 165-245) (HRP) (ABIN891970)

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Reactivity: Human, Rat, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Corin antibody is conjugated to HRP

Application: ELISA

Product Details anti-Corin Antibody (HRP)

Binding Specificity: AA 165-245

Cross-Reactivity: Human, Rat, Sheep

Predicted Reactivity: Mouse,Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Corin

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Corin

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Alternative Name: Corin

Background:

Synonyms: CRN, ATC2, Lrp4, PEE5, TMPRSS10, Atrial natriuretic peptide-converting enzyme, Corin, Heart-specific serine proteinase ATC2, Pro-ANP-converting enzyme, Transmembrane protease serine 10

Background: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared to isoform 1.

Gene ID: 10699

UniProt: Q9Y5Q5

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones