Corin antibody (PE)

Catalog No. ABIN891982

This Rabbit Polyclonal antibody specifically detects Corin in IF (p). It exhibits reactivity toward Human, Rat, Mouse, Pig and Dog.

Quick Overview for Corin antibody (PE) (ABIN891982)

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Reactivity: Human, Rat, Mouse, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Corin antibody is conjugated to PE

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Corin Antibody (PE)

Specificity: Excitation / Emission Wavelengths: 565nm/578nm

Cross-Reactivity: Rat (Rattus), Dog (Canine), Pig (Porcine)

Purification: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human Corin

Isotype: IgG

Application Details

Comment:

Excitation / Emission wavelength: 496nm / 578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4 °C for 12 months

Expiry Date: 12 months

Target Details for Corin

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Alternative Name: Corin

Background: Corin was first described as a trypsin-like serine proteinase in the heart which processed pro-atrial natriuretic peptide into the active form ANP. Corin cleaves pro-ANP at Arg98/Ser-99, and blocking Corin message inhibits pro-ANP processing. Null mutant mice lacking Corin develop hypertension, and a series of missense mutations have been identified in humans with high blood pressure and hypertension. Corin is a member of the type-II transmembrane serine proteinases, such as Hepsin, Epitheliasin, Matriptase and enteropeptidase. The Corin domain structure includes a cytoplasmic domain, a transmembrane domain, a spacer region, a frizzled-like domain, 5 LDL Receptor-like domains, another frizzled-like domain, 3 more LDLR-like repeats, a SRCR (Scavenger Receptor-Cysteine Rich) domain (also called macrophage scavenger-like domain), and finally the trypsin-like serine proteinase domain. The complex domain structure puts Corin into the ﾓmosaicﾔ TMPRSS family, so named because of the wide variety of domains.

Molecular Weight: 117kDa

Gene ID: 10699

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones