Dynactin 1 antibody (AA 251-350) (AbBy Fluor® 647)

Catalog No. ABIN893645

The Rabbit Polyclonal anti-Dynactin 1 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect Dynactin 1 in samples from Human.

Quick Overview for Dynactin 1 antibody (AA 251-350) (AbBy Fluor® 647) (ABIN893645)

Target: Dynactin 1 (DCTN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynactin 1 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Dynactin 1 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 251-350

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DCTN1/Dynactin 1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Dynactin 1

Target: Dynactin 1 (DCTN1)

Alternative Name: DCTN1

Background:

Synonyms: Alternative names150 kDa dynein associated polypeptide, 150 kDa dynein-associated polypeptide, DAP 150, DAP-150, DAP150, DCTN 1, DCTN1, DCTN1_HUMAN, DP 150, DP-150, DP150, Dynactin 1 p150 Glued Drosophila homolog, Dynactin 1 p150 glued homolog Drosophila, Dynactin 1, Dynactin subunit 1, Dynactin1, HMN7B, P135, p150 Glued Drosophila homolog, p150 glued, p150 glued homolog, p150GLUED DROSOPHILA HOMOLOG OF, p150-glued, p150glued.

Background: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.Tissue specificity, Brain.Involvement in disease, Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B), also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Defects in DCTN1 are the cause of Perry syndrome (PERRYS), also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.

Gene ID: 1639

Pathways: M Phase, ER-Nucleus Signaling