DUSP26 antibody (AA 144-211) (Biotin)

Catalog No. ABIN894581

The Rabbit Polyclonal anti-DUSP26 antibody has been validated for ELISA, WB, IHC (p) and IHC (fro). It is suitable to detect DUSP26 in samples from Rat.

Quick Overview for DUSP26 antibody (AA 144-211) (Biotin) (ABIN894581)

Target: DUSP26 (Dual Specificity Phosphatase 26 (DUSP26))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP26 antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-DUSP26 Antibody (Biotin)

Binding Specificity: AA 144-211

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DUSP26/MKP8

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DUSP26

Target: DUSP26 (Dual Specificity Phosphatase 26 (DUSP26))

Alternative Name: DUSP26

Background:

Synonyms: DSP-4, Dual specicity phosphatase 26 putative, Dual specicity phosphatase 26, Dual specicity phosphatase SKRP3, Dual specicity protein phosphatase 26, DUS26_HUMAN, DUSP24, DUSP26, Hypothetical protein FLJ31142, LDP 4, LDP-4, Low molecular mass dual specicity phosphatase 4, Low-molecular-mass dual-specicity phosphatase 4, MAP kinase phosphatase 8, MGC1136, MGC2627, Mitogen activated protein kinase phosphatase 8, Mitogen-activated protein kinase phosphatase 8, MKP-8, MKP8, NATA1, NATA1 protein, Novel amplied gene in thyroid anaplastic cancer, SKRP3.

Background: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.