HTRA2 antibody (AA 355-458) (AbBy Fluor® 555)

Catalog No. ABIN901506

This anti-HTRA2 antibody is a Rabbit Polyclonal antibody detecting HTRA2 in WB, IF (p) and IF (cc). Suitable for Human, Mouse and Rat.

Quick Overview for HTRA2 antibody (AA 355-458) (AbBy Fluor® 555) (ABIN901506)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA2 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-HTRA2 Antibody (AbBy Fluor® 555)

Binding Specificity: AA 355-458

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HtrA2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HtrA2/Omi

Background:

Synonyms: High temperature requirement protein a2, HTRA 2, HtrA like serine protease, HtrA serine peptidase 2, Omi stress regulated endoprotease, PARK 13, PARK13, Protease serine 25, PRSS 25, PRSS25, Serine protease 25, Serine protease HTRA2 mitochondrial, HtrA2, HTRA2_HUMAN, mitochondrial, Omi stress-regulated endoprotease, Serine protease HTRA2, Serine proteinase OMI, Serine protease htra2 mitochondrial precursor, Serine protease omi.

Background: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins(also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Isoform 2 seems to be proteolytically inactive. [CATALYTIC ACTIVITY] Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues. [SUBUNIT] Homotrimer. Interacts with MXI2. The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.

Gene ID: 27429

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity