SAMHD1 antibody (AA 256-370) (Biotin)

Catalog No. ABIN914313

This anti-SAMHD1 antibody is a Rabbit Polyclonal antibody detecting SAMHD1 in WB, ELISA, IHC (p) and IHC (fro). Suitable for Mouse.

Quick Overview for SAMHD1 antibody (AA 256-370) (Biotin) (ABIN914313)

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAMHD1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SAMHD1 Antibody (Biotin)

Binding Specificity: AA 256-370

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SAMHD1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SAMHD1

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Alternative Name: SAMHD1

Background:

Synonyms: DCIP, Dendritic cell derived NG induced protein, Dendritic cell-derived NG-induced protein, HD domain containing 1, HDDC1, Mg11, Monocyte protein 5, MOP 5, MOP5, OTTHUMP00000030889, SAM domain and HD domain 1, SAM domain and HD domain containing protein 1, SAM domain and HD domain-containing protein 1, SAMH1_HUMAN, Samhd1, SBBI88.

Background: Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling.Tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.Involvement in disease:Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) . A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.

Gene ID: 4861

UniProt: Q9Y3Z3