TXNDC5 antibody (AA 251-350) (HRP)

Catalog No. ABIN919069

This Rabbit Polyclonal antibody specifically detects TXNDC5 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for TXNDC5 antibody (AA 251-350) (HRP) (ABIN919069)

Target: TXNDC5 (Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) (TXNDC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNDC5 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TXNDC5 Antibody (HRP)

Binding Specificity: AA 251-350

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TXNDC5

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TXNDC5

Target: TXNDC5 (Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) (TXNDC5))

Alternative Name: TXNDC5

Background:

Synonyms: EndoPDI, Endoplasmic reticulum protein ERp46, Endothelial protein disulphide isomerase, ERP46, Hcc 2, PDIA15, Protein disulfide isomerase family A member 15, Thioredoxin domain containing 5 endoplasmic reticulum, thioredoxin domain containing 5, Thioredoxin domain containing protein 5, Thioredoxin like protein p46, Thioredoxin related protein, Thioredoxin-like protein p46, TLP46, TXN5, TXNDC 5, UNQ364, TXND5_HUMAN.

Background: TXNDC5 is a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. ERp19 and ERp46 are two newly discovered ER luminal proteins, related to protein disulphide isomerase. Western and Northern blot analyses have revealed that both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues. Both proteins are enriched in purified liver ER vesicles and were localized specifically to the ER in McA-RH7777 hepatocytes. See Knoblach et al. for details.

Gene ID: 81567

Pathways: Cell RedoxHomeostasis