XBP1 antibody (AA 51-150) (AbBy Fluor® 647)

Catalog No. ABIN920156

The Rabbit Polyclonal anti-XBP1 antibody has been validated for WB, FACS, IF (cc) and IF (p). It is suitable to detect XBP1 in samples from Human and Mouse.

Quick Overview for XBP1 antibody (AA 51-150) (AbBy Fluor® 647) (ABIN920156)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XBP1 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-XBP1 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 51-150

Specificity: XBP-1 antibody will recognize both isoforms, may also interact with chicken

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human XBP-1

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Alternative Name: Xbp1

Background:

Synonyms: XBP2, TREB5, XBP-1, X-box-binding protein 1, Tax-responsive element-binding protein 5, XBP1

Background: Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.

Gene ID: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response