Glucocorticoid Receptor antibody (N-Term)

Catalog No. ABIN927317

The Rabbit Polyclonal anti-Glucocorticoid Receptor antibody has been validated for WB. It is suitable to detect Glucocorticoid Receptor in samples from Human.

Quick Overview for Glucocorticoid Receptor antibody (N-Term) (ABIN927317)

Target: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glucocorticoid Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Glucocorticoid Receptor Antibody

Binding Specificity: N-Term

Purification: Purified

Immunogen: NR3 C1 antibody was raised in rabbit using the N terminal of NR3 1 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

NR3C1 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this NR3C1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Glucocorticoid Receptor

Target: Glucocorticoid Receptor (NR3C1) (Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))

Alternative Name: NR3C1

Background: NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Synonyms: Polyclonal NR3C1 antibody, Anti-NR3C1 antibody, nuclear receptor subfamily 3, group C, member 1, glucocorticoid receptor antibody, GCCR antibody, GCR antibody, GR antibody, GRL antibody.

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process