GAD antibody (N-Term)

Catalog No. ABIN928718

The Rabbit Polyclonal anti-GAD antibody has been validated for WB and IHC. It is suitable to detect GAD in samples from Human and Mouse.

Quick Overview for GAD antibody (N-Term) (ABIN928718)

Target: GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GAD Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: Gad1 antibody was raised in rabbit using the N terminal of Gad1 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

Gad1 Blocking Peptide, (ABIN5613700), is also available for use as a blocking control in assays to test for specificity of this Gad1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for GAD

Target: GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))

Alternative Name: Gad1

Background: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in  insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with  seizures. Synonyms: Polyclonal Gad1 antibody, Anti-Gad1 antibody, glutamic acid decarboxylase 1 antibody.