USP10 antibody (C-Term)

Catalog No. ABIN929190

This anti-USP10 antibody is a Rabbit Polyclonal antibody detecting USP10 in WB. Suitable for Human and Rat.

Quick Overview for USP10 antibody (C-Term) (ABIN929190)

Target: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-USP10 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Rat (Rattus)

Purification: Purified

Immunogen: Usp10 antibody was raised in rabbit using the C terminal of Usp10 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

Usp10 Blocking Peptide, (ABIN5616928), is also available for use as a blocking control in assays to test for specificity of this Usp10 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for USP10

Target: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Alternative Name: Usp10

Background: Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Synonyms: Polyclonal Usp10 antibody, Anti-Usp10 antibody, ubiquitin specific peptidase 10 antibody, MGC124997 antibody.