Complex IV Subunit VIb (AA 58-86), (C-Term) antibody

Catalog No. ABIN951654

This anti- antibody is a Rabbit Polyclonal antibody detecting in EIA, IHC (p) and WB. Suitable for Human.

Quick Overview for Complex IV Subunit VIb (AA 58-86), (C-Term) antibody (ABIN951654)

Target: Complex IV Subunit VIb

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Product Details

Binding Specificity: AA 58-86, C-Term

Specificity: This antibody reacts to COX6B1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 58-86 amino acids from the C-terminal region of human COX6B1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details

Target: Complex IV Subunit VIb

Background: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.Synonyms: COX6B, COX6B1, Cytochrome c oxidase subunit 6B1, Mitochondria Complex IV

Molecular Weight: 10192 Da

Gene ID: 1340

NCBI Accession: NP_001854