CXXC1 antibody (Middle Region)

Catalog No. ABIN951679

This Rabbit Polyclonal antibody specifically detects CXXC1 in WB and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for CXXC1 antibody (Middle Region) (ABIN951679)

Target: CXXC1 (CXXC Finger Protein 1 (CXXC1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXXC1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-CXXC1 Antibody

Binding Specificity: AA 325-354, Middle Region

Specificity: This antibody detects CpG-binding protein/CXXC1 (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse

Purification: Purified through a protein A column; followed by peptide affinity purification.

Immunogen: KLH conjugated synthetic peptide from the central region (between 325-354 aa) of Human CpG-binding protein/CXXC1.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CXXC1

Target: CXXC1 (CXXC Finger Protein 1 (CXXC1))

Alternative Name: CpG-Binding Protein

Background: Human CpG binding protein (hCGBP) contains three cysteine-rich domains, two of which exhibit homology to the plant homeodomain finger domain and the third cysteine-rich domain conforms to the CXXC motif identified in DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. A fragment of hCGBP that contains the CXXC domain binds to an oligonucleotide probe containing a single CpG site, and this complex is disrupted by distinct oligonucleotide competitors that also contain a CpG motif(s). CBGP plays an important part in embryonic viability and peri-implantation development. Native hCGBP is detected as an 88- kDa protein by Western analysis and is ubiquitously expressed. CGBP trans-activates promoters that contain CpG motifs but not promoters in which the CpG is ablated suggesting that hCGBP is a transcriptional activator that recognizes unmethylated CpG dinucleotides.Synonyms: CFP1, CGBP, CXXC-type zinc finger protein 1, CXXC1, PCCX1, PHD finger and CXXC domain-containing protein 1, PHF18

Gene ID: 30827

NCBI Accession: NP_001095124

Pathways: ER-Nucleus Signaling