GREM1 antibody (C-Term)

Catalog No. ABIN952628

The Rabbit Polyclonal anti-GREM1 antibody has been validated for WB and EIA. It is suitable to detect GREM1 in samples from Human.

Quick Overview for GREM1 antibody (C-Term) (ABIN952628)

Target: GREM1 (Gremlin 1 (GREM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GREM1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-GREM1 Antibody

Binding Specificity: AA 110-139, C-Term

Specificity: This antibody recognizes Human Gremlin-1 / GREM1 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 110-139 amino acids from the C-terminal region of Human Gremlin-1 / GREM1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Alternative Name: Gremlin-1 / GREM1

Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Synonyms: CKTSF1B1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1 BMP antagonist 1, DAN domain family member 2, DAND2, DRM, GREM-1, IHG-2, PIG2

Molecular Weight: 20697 Da

Gene ID: 26585

NCBI Accession: NP_001178252

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location