GUCY2D antibody (Middle Region)

Catalog No. ABIN952663

This Rabbit Polyclonal antibody specifically detects GUCY2D in WB, FACS, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for GUCY2D antibody (Middle Region) (ABIN952663)

Target: GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCY2D antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-GUCY2D Antibody

Binding Specificity: AA 547-578, Middle Region

Specificity: This antibody recognizes Human GUCY2D / RETGC1 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 547-578 amino acids from the Central region of human GUCY2D / RETGC1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GUCY2D

Target: GUCY2D (Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D))

Alternative Name: GUCY2D / RETGC1

Background: This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq].Synonyms: CORD6, GUC1A4, GUC2D, PGCD, RETGC, RETGC-1, Retinal guanylyl cyclase 1, Rod outer segment membrane guanylate cyclase, retinal Guanylate cyclase 2D

Molecular Weight: 120059 Da

Gene ID: 3000

NCBI Accession: NP_000171

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction