XDH antibody (N-Term)

Catalog No. ABIN955594

This Rabbit Polyclonal antibody specifically detects XDH in WB, IHC (p) and EIA. It exhibits reactivity toward Human and Mouseand has been mentioned in 1 publication.

Quick Overview for XDH antibody (N-Term) (ABIN955594)

Target: XDH (Xanthine Dehydrogenase (XDH))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XDH antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-XDH Antibody

Binding Specificity: AA 213-242, N-Term

Specificity: This antibody detects Xanthine dehydrogenase/oxidase (N-term).

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse.

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 213~242 amino acids from the N-terminal region of human XDH

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

References for anti-XDH antibody (ABIN955594)

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Target Details for XDH

Target: XDH (Xanthine Dehydrogenase (XDH))

Alternative Name: XDH

Background: XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.Synonyms: Xanthine dehydrogenase/oxidase

Gene ID: 7498

NCBI Accession: NP_000370

Pathways: Positive Regulation of Endopeptidase Activity