Calpain 3 antibody (C-Term)

Catalog No. ABIN965743

This Rabbit Polyclonal antibody specifically detects Calpain 3 in IHC. It exhibits reactivity toward Human.

Quick Overview for Calpain 3 antibody (C-Term) (ABIN965743)

Target: Calpain 3 (CAPN3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Calpain 3 Antibody

Binding Specificity: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CAPN3(Calpain-3)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Calpain 3

Target: Calpain 3 (CAPN3)

Alternative Name: CAPN3

Background: CAPN3(Calpain-3) is a calcium-regulated non-lysosomal thiol-protease. It has a broad endopeptidase specificity. CAPN3 is activated by micromolar concentrations of calcium and inhibited by calpastatin. It interacts with TTN/titin. Isoform I is skeletal muscle specific. Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A). LGMD2A is both autosomal dominantly and recessively transmitted. It is characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. CAPN3 belongs to the peptidase C2 family and contains 1 calpain catalytic domain and 4 EF-hand domains.

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development