Laminin antibody

Catalog No. ABIN966476

Product Details anti-Laminin Antibody

Target: Laminin (LN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Laminin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Cat (Feline), Pig (Porcine)

Cross-Reactivity (Details): No cross reactivity with other proteins.

Immunogen: Human laminin.

Clone: Lam-26

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 1.2 % sodium acetate or neutral PBS. If 1 mL of PBS is used, the antibody concentration will be 100 µg/mL.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

References for anti-Laminin antibody (ABIN966476)

Zhang, Vuolteenaho, Tryggvason: "Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy." in: The Journal of biological chemistry, Vol. 271, Issue 44, pp. 27664-9, (1996) (PubMed).

Arahata, Hayashi, Mizuno, Yoshida, Ozawa: "Dystrophin-associated glycoprotein and dystrophin co-localisation at sarcolemma in Fukuyama congenital muscular dystrophy." in: Lancet (London, England), Vol. 342, Issue 8871, pp. 623-4, (1993) (PubMed).

Ehrig, Leivo, Argraves, Ruoslahti, Engvall: "Merosin, a tissue-specific basement membrane protein, is a laminin-like protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 9, pp. 3264-8, (1990) (PubMed).

Target Details for Laminin

Target: Laminin (LN)

Alternative Name: Laminin (LN Products)

Background: Laminin is a heterotrimeric extracellular matrix protein consisting of 3 chains: alpha-1,beta-1 and gamma-1, formerly called beta-2 (LAMA2). This gene is over 260, 000 base pairs and contains 64 exons. Laminin is similar with merosin, a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve, and both of them are members of the same family of basement membrane proteins. And merosin is the same as laminin M, a striated muscle-specific, basal-lamina-associated protein, it may play a primary role in the pathogenesis of that disorder.

Gene ID: 284217, 16772, 316758

UniProt: P02469, P15800, Q61292, D3ZQN7, P07942, Q60675, P19137, P55268, D4A409, P25391, F1M614, P24043