TRIM25 antibody (N-Term)

Catalog No. ABIN967204

This Rabbit Polyclonal antibody specifically detects TRIM25 in IHC. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for TRIM25 antibody (N-Term) (ABIN967204)

Target: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM25 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-TRIM25 Antibody

Binding Specificity: N-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human TRIM25 (Tripartite motif-containing protein 25)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-TRIM25 antibody (ABIN967204)

Inoue, Orimo, Hosoi, Kondo, Toyoshima, Kondo, Ikegami, Ouchi, Orimo, Muramatsu: "Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 23, pp. 11117-21, (1994) (PubMed).

Target Details for TRIM25

Target: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Alternative Name: TRIM25

Background: TRIM25 (Tripartite motif-containing protein 25) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a Bbox type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of TRIM25 is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary TRIM25 contains 1 B30.2/SPRY domain and 1 RING-type zinc finger.
Synonyms: EFP (Estrogen-responsive finger protein), RNF147 (RING finger protein 147), ZNF147 (Zinc finger protein 147)