SORL1 antibody (AA 1220-1337)

Catalog No. ABIN968682

Product Details anti-SORL1 Antibody

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Binding Specificity: AA 1220-1337

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Rat (Rattus), Mouse (Murine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human LR11 aa. 1220-1337

Clone: 48-LR11

Isotype: IgG2a

Application Details

Comment:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-SORL1 antibody (ABIN968682)

Doering, Kane, Hsiao, Yao, Shi, Slowik, Dhagat, Scott, Ault, Page-McCaw, Ferland: "Species differences in the expression of Ahi1, a protein implicated in the neurodevelopmental disorder Joubert syndrome, with preferential accumulation to stigmoid bodies." in: The Journal of comparative neurology, Vol. 511, Issue 2, pp. 238-56, (2008) (PubMed).

Posse De Chaves, Vance, Campenot, Kiss, Vance: "Uptake of lipoproteins for axonal growth of sympathetic neurons." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19883-90, (2000) (PubMed).

Jacobsen, Madsen, Moestrup, Lund, Tommerup, Nykjaer, Sottrup-Jensen, Gliemann, Petersen: "Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein." in: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31379-83, (1997) (PubMed).

Yamazaki, Bujo, Kusunoki, Seimiya, Kanaki, Morisaki, Schneider, Saito: "Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member." in: The Journal of biological chemistry, Vol. 271, Issue 40, pp. 24761-8, (1996) (PubMed).

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: LR11 (SORL1 Products)

Background: The low-density lipoprotein receptor (LDLR) functions in lipoprotein transport pathways, and is involved in familial hypercholesterolemia. Homologues of the LDLR may have diverse functions and their ligands may include biological inactive plasma carrier complexes, plasma lipoproteins, yolk precursors, toxins, and extracellular lipoproteins. LR11 (also known as sorLA-1 and gp250) is a lipoprotein receptor homologue that contains 11 LDL receptor ligand binding repeats (LDLRs), 5 LDL receptor YWTDrepeats, a large fibronectin-type III (FIII) hexarepeat domain similar to neural adhesion proteins, and a domain with similarity to the yeast receptor for vacuolar protein sorting (Vsp10p). LR11mRNA is expressed at high levels in brain, but is also found in liver, pancreas, adrenal gland, and testis. LR11 can bind the ER and Golgi localized receptor associated protein (RAP), which binds to many members of the LDLR family and prevents aggregation of ligands to the LDLRs. In addition, LR11 binds apolipoprotein E-containing lipoproteins. Thus, LR11 is a lipoprotein binding receptor that may have additional functions related to protein sorting and neuronal development.
Synonyms: SorLA, gp250, Lipoprotein Receptor-11

Molecular Weight: 250 kDa

Pathways: Smooth Muscle Cell Migration