AGT antibody

Catalog No. ABIN968948

Product Details anti-AGT Antibody

Target: AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AGT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: AGT Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human AGT expressed in E. Coli.

Clone: 1B1

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-AGT antibody (ABIN968948)

Xu, Carretero, Lin, Cavasin, Shesely, Yang, Reudelhuber, Yang: "Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction." in: American journal of physiology. Heart and circulatory physiology, Vol. 293, Issue 3, pp. H1900-7, (2007) (PubMed).

Rossi, Zappa, Ferraresi, Santiemma: "Adrenomedullin inhibits angiotensin II-induced contraction in human aortic smooth muscle cells." in: Regulatory peptides, Vol. 133, Issue 1-3, pp. 155-9, (2005) (PubMed).

Target Details for AGT

Target: AGT (Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT))

Alternative Name: AGT (AGT Products)

Background:

Description: AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Aliases: ANHU

Molecular Weight: 53kDa

Gene ID: 183

HGNC: 183

UniProt: P01019

Pathways: JAK-STAT Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity