Calnexin antibody

Catalog No. ABIN969000

This anti-Calnexin antibody is a Mouse Monoclonal antibody detecting Calnexin in WB, ELISA and ICC. Suitable for Human. This Primary Antibody has been cited in 3+ publications.

Quick Overview for Calnexin antibody (ABIN969000)

Target: Calnexin (CANX)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Calnexin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Clone: 3H4A7

Product Details anti-Calnexin Antibody

Purpose: Calnexin Antibody

Sequence: CEAAEERPWL WVVYILTVAL

Purification: Ascitic fluid

Immunogen: Synthetic peptide corresponding to aa (CEAAEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Calnexin antibody (ABIN969000)

Orlando: "The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient fibroblasts." in: Experimental cell research, Vol. 294, Issue 1, pp. 244-53, (2004) (PubMed).

Egan, Pearson, Weiner, Rajendran, Rubin, Glöckner-Pagel, Canny, Du, Lukacs, Caplan: "Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects." in: Science (New York, N.Y.), Vol. 304, Issue 5670, pp. 600-2, (2004) (PubMed).

Oda, Hosokawa, Wada, Nagata: "EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin." in: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1394-7, (2003) (PubMed).

Target Details for Calnexin

Target: Calnexin (CANX)

Alternative Name: Calnexin

Background: This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.

Molecular Weight: 90 kDa

Gene ID: 821

UniProt: P27824

Pathways: MAPK Signaling, Thyroid Hormone Synthesis