KRT17 antibody

Catalog No. ABIN969058

This Mouse Monoclonal antibody specifically detects KRT17 in WB, IHC and ELISA. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for KRT17 antibody (ABIN969058)

Target: KRT17 (Keratin 17 (KRT17))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT17 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 3B12

Product Details anti-KRT17 Antibody

Purpose: CK17 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of CK17 expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KRT17 antibody (ABIN969058)

van de Rijn, Perou, Tibshirani, Haas, Kallioniemi, Kononen, Torhorst, Sauter, Zuber, Köchli, Mross, Dieterich, Seitz, Ross, Botstein, Brown: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." in: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).

Target Details for KRT17

Target: KRT17 (Keratin 17 (KRT17))

Alternative Name: CK17

Background: CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

Molecular Weight: 49 kDa

Gene ID: 3872

UniProt: Q04695