Estrogen Receptor alpha antibody (Estrogen Receptor 1) (AA 130-339)

Details for Product anti-ESR1 Antibody No. ABIN969117
Target
Binding Specificity
AA 130-339
43
31
29
27
26
24
23
21
21
18
17
16
16
16
15
15
15
13
11
11
10
8
7
6
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
593
255
206
40
33
12
10
9
7
7
5
5
4
3
3
1
1
Host
Mouse
453
176
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
42
24
24
17
16
13
12
12
12
12
12
11
6
6
6
6
6
4
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
445
211
207
143
103
80
79
55
55
18
16
16
13
13
11
9
7
3
2
1
1
1
1
1
1
1
1
1
1
1
Options
Immunogen Purified recombinant fragment of ESR1 (aa130-339) expressed in E. Coli.
Clone 8H9A10
Isotype IgG1
Purification Ascites
Target
Alternative Name ESR1 (ESR1 Antibody Abstract)
Background ESR1: estrogen receptor 1. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Gene ID 2099
HGNC 2099
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Images
Image no. 1 for anti-Estrogen Receptor 1 (ESR1) (AA 130-339) antibody (ABIN969117) Figure 1: Western blot analysis using ESR1 mouse mAb against truncated Trx-ESR1 recom...
Product cited in: Cepollaro, Lauretani, Gozzini, Masi, Falchetti, Del Monte, Carbonell-Sala, Tanini, Corsi, Bandinelli, Ferrucci, Brandi: "Relationship of volumetric bone mineral density and structural parameters with ERalpha gene polymorphisms." in: Calcified tissue international, Vol. 80, Issue 5, pp. 307-15, 2007 (PubMed).