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Estrogen Receptor alpha antibody (AA 246-273)

ESR1 Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal RB33807 unconjugated
Catalog No. ABIN657470
  • Target See all Estrogen Receptor alpha (ESR1) Antibodies
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Binding Specificity
    • 32
    • 30
    • 26
    • 23
    • 21
    • 21
    • 21
    • 16
    • 16
    • 16
    • 16
    • 16
    • 16
    • 15
    • 14
    • 12
    • 12
    • 10
    • 10
    • 10
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    AA 246-273
    Reactivity
    • 487
    • 173
    • 168
    • 19
    • 18
    • 10
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 398
    • 98
    • 2
    • 1
    Rabbit
    Clonality
    • 377
    • 124
    Polyclonal
    Conjugate
    • 223
    • 35
    • 24
    • 22
    • 19
    • 15
    • 15
    • 15
    • 15
    • 15
    • 15
    • 11
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    This Estrogen Receptor alpha antibody is un-conjugated
    Application
    • 294
    • 163
    • 142
    • 121
    • 98
    • 94
    • 80
    • 66
    • 40
    • 39
    • 24
    • 15
    • 10
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, Hs, Pig, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ESR1/ER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-273 amino acids from the Central region of human ESR1/ER.
    Clone
    RB33807
    Isotype
    Ig Fraction
  • Application Notes
    IF: 1:10~50. WB: 1:2000. WB: 1:2000. IHC-P: 1:100. IHC-P: 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    ESR1/ER Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Expiry Date
    6 months
  • Zhu, Xu, Rashedi, Pavone, Kim, Woodruff, Burdette: "Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle." in: Molecular human reproduction, Vol. 22, Issue 11, pp. 756-767, (2018) (PubMed).

    Wang, Zhou, Guan, Yu, Wang: "β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway." in: Toxicology, Vol. 394, pp. 1-10, (2018) (PubMed).

    Arslan, Yu, Burdette, Pavone, Hope, Woodruff, Kim: "Novel three dimensional human endocervix cultures respond to 28-day hormone treatment." in: Endocrinology, Vol. 156, Issue 4, pp. 1602-9, (2015) (PubMed).

    Bi, Yang, Yu, Zhao, Zhao, He, Jing, Wang, Huang: "Pregnancy serum facilitates hepatitis E virus replication in vitro." in: The Journal of general virology, Vol. 96, Issue Pt 5, pp. 1055-61, (2015) (PubMed).

  • Target
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Alternative Name
    ESR1/ER (ESR1 Products)
    Synonyms
    LOC398734 antibody, AA420328 antibody, AU041214 antibody, ER-alpha antibody, ER[a] antibody, ERa antibody, ERalpha antibody, ESR antibody, Estr antibody, Estra antibody, Nr3a1 antibody, NR3A1 antibody, eralpha antibody, zfER[a] antibody, ER antibody, ESRA antibody, ESTRR antibody, Era antibody, akap12 antibody, cb27 antibody, esr1 antibody, fb72g12 antibody, id:ibd1202 antibody, sb:cb27 antibody, si:ch73-192g21.1 antibody, wu:fb72g12 antibody, wu:fc21c03 antibody, Esr antibody, RNESTROR antibody, ERALPHA antibody, er antibody, esr antibody, nr3a1 antibody, XER antibody, era antibody, esra antibody, ERbeta antibody, xesr-1 antibody, xlERalpha1 antibody, xlERalpha2 antibody, ESR1 antibody, estrogen receptor 1 L homeolog antibody, estrogen receptor 1 (alpha) antibody, estrogen receptor 1 antibody, A kinase (PRKA) anchor protein 12b antibody, esr1.L antibody, Esr1 antibody, ESR1 antibody, esr1 antibody, akap12b antibody
    Background
    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
    Molecular Weight
    66216
    Gene ID
    2099
    NCBI Accession
    NP_000116, NP_001116212, NP_001116213, NP_001116214
    UniProt
    P03372
    Pathways
    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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