Estrogen Receptor alpha antibody (Estrogen Receptor 1)

Details for Product anti-ESR1 Antibody No. ABIN969119
Target
Reactivity
Human
566
238
203
40
33
12
10
9
7
7
5
5
4
3
3
1
1
Host
Mouse
434
168
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
42
24
24
18
16
13
13
12
12
12
12
11
6
6
6
6
6
4
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
422
198
186
139
87
82
77
55
54
18
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11
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6
3
2
1
1
1
1
1
1
1
1
1
1
1
Options
Immunogen Purified recombinant fragment of human ESR1 expressed in E. Coli.
Clone 6B6
Isotype IgG1
Purification Ascites
Target
Alternative Name ESR1 (ESR1 Antibody Abstract)
Background This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
Molecular Weight 66 kDa
Gene ID 2099
HGNC 2099
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Images
Image no. 1 for anti-Estrogen Receptor 1 (ESR1) antibody (ABIN969119) Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues us...
Image no. 2 for anti-Estrogen Receptor 1 (ESR1) antibody (ABIN969119) Figure 3: Western blot analysis using ESR1 mouse mAb against MCF-7 (1), T47D (2) and ...
Image no. 3 for anti-Estrogen Receptor 1 (ESR1) antibody (ABIN969119) Figure 1: Immunofluorescence analysis of Hela cells using ESR1 mouse mAb (green) . Re...
Product cited in: Deegan, Seldeen, McDonald, Bhat, Farooq: "Binding of the ERalpha nuclear receptor to DNA is coupled to proton uptake." in: Biochemistry, Vol. 49, Issue 29, pp. 5978-88, 2010 (PubMed).

Harsløf, Husted, Carstens, Stenkjaer, Langdahl: "Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis." in: Calcified tissue international, Vol. 87, Issue 1, pp. 25-35, 2010 (PubMed).