FOXP3 antibody

Catalog No. ABIN969156

This anti-FOXP3 antibody is a Mouse Monoclonal antibody detecting FOXP3 in ELISA. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for FOXP3 antibody (ABIN969156)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOXP3 antibody is un-conjugated

Application: ELISA

Clone: 4C7

Product Details anti-FOXP3 Antibody

Purpose: FOXP3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FOXP3 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FOXP3 antibody (ABIN969156)

Yuan, Chen, Li, Dong, Xue, Wang, Zhang, Wang, Zhang, Ge, Shen, Xu: "Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner." in: Clinical immunology (Orlando, Fla.), Vol. 134, Issue 3, pp. 277-88, (2010) (PubMed).

Sarigul, Yazisiz, Bassorgun, Ulker, Avci, Erbasan, Gelen, Gorczynski, Terzioglu: "The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome." in: Lupus, Vol. 19, Issue 2, pp. 138-45, (2010) (PubMed).

Target Details for FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Alternative Name: FOXP3

Background: FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.

Molecular Weight: 47.2 kDa

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation