GATA3 antibody

Catalog No. ABIN969168

This anti-GATA3 antibody is a Mouse Monoclonal antibody detecting GATA3 in ELISA and IHC. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for GATA3 antibody (ABIN969168)

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GATA3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 7B5

Product Details anti-GATA3 Antibody

Purpose: GATA3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human GATA3 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-GATA3 antibody (ABIN969168)

Muzzioli, Stecconi, Moresi, Provinciali: "Zinc improves the development of human CD34+ cell progenitors towards NK cells and increases the expression of GATA-3 transcription factor in young and old ages." in: Biogerontology, Vol. 10, Issue 5, pp. 593-604, (2009) (PubMed).

van Hamburg, Mus, de Bruijn, de Vogel, Boon, Cornelissen, Asmawidjaja, Hendriks, Lubberts: "GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis." in: Arthritis and rheumatism, Vol. 60, Issue 3, pp. 750-9, (2009) (PubMed).

Target Details for GATA3

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Alternative Name: GATA3

Background: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. (provided by RefSeq) Tissue specificity: T-cells and endothelial cells RD: GATA-3 belongs to the GATA family of transcription factors, which bind to the consensus DNA sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and morphogenesis. It is widely expressed in mesodermal- and endodermal-derived tissues. GATA-3 has been shown to be an essential regulator for immune cell function, sympathetic neuron development, and the maintenance of the differentiated state in epithelial cells.

Molecular Weight: 48 kDa

Gene ID: 2625

UniProt: P23771

Pathways: Hormone Transport, Regulation of Hormone Metabolic Process, Tube Formation