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PAX8 antibody

This Mouse Monoclonal antibody specifically detects PAX8 in WB and ELISA. It exhibits reactivity toward Humanand has been mentioned in 1 publication.
Catalog No. ABIN969343

Quick Overview for PAX8 antibody (ABIN969343)

Target

See all PAX8 Antibodies
PAX8 (Paired Box 8 (PAX8))

Reactivity

  • 117
  • 49
  • 42
  • 20
  • 20
  • 7
  • 6
  • 5
  • 4
  • 2
  • 2
  • 1
Human

Host

  • 81
  • 37
  • 1
Mouse

Clonality

  • 62
  • 57
Monoclonal

Conjugate

  • 66
  • 8
  • 6
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This PAX8 antibody is un-conjugated

Application

  • 89
  • 38
  • 36
  • 31
  • 28
  • 19
  • 14
  • 12
  • 11
  • 10
  • 6
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA

Clone

2D4
  • Purpose

    PAX8 Antibody

    Purification

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of human PAX8 expressed in E. Coli.

    Isotype

    IgG1
  • Application Notes

    ELISA: 1/10000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • McKnight, Cohen, Siddiqui: "Utility of paired box gene 8 (PAX8) expression in fluid and fine-needle aspiration cytology: an immunohistochemical study of metastatic ovarian serous carcinoma." in: Cancer cytopathology, Vol. 118, Issue 5, pp. 298-302, (2010) (PubMed).

  • Target

    PAX8 (Paired Box 8 (PAX8))

    Alternative Name

    PAX8

    Background

    This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas.Tissue specificity: Expressed in the excretory system, thyroid gland and Wilms tumors.ABCAM: This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells.

    Molecular Weight

    60 kDa

    Gene ID

    7849

    UniProt

    P27930

    Pathways

    Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation
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