WNT1 antibody

Catalog No. ABIN969458

Product Details anti-WNT1 Antibody

Target: WNT1 (Wingless-Type MMTV Integration Site Family, Member 1 (WNT1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This WNT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: WNT1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of WNT1 expressed in E. Coli.

Clone: 10C8

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-WNT1 antibody (ABIN969458)

Toffart, Moro-Sibilot, Couraud, Merle, Perol, Girard, Souquet, Mastroianni, Ferretti, Romand, Chatellain, Vesin, Brambilla, Brambilla, Timsit: "Evaluation of RECIST in chemotherapy-treated lung cancer: the Pharmacogenoscan Study." in: BMC cancer, Vol. 14, pp. 989, (2015) (PubMed).

Target Details for WNT1

Target: WNT1 (Wingless-Type MMTV Integration Site Family, Member 1 (WNT1))

Alternative Name: WNT1 (WNT1 Products)

Background:

Description: WNT1: wingless-type MMTV integration site family, member 1. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98 % identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant rolein Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

Aliases: INT1

Molecular Weight: 41kDa

Gene ID: 7471

HGNC: 7471

UniProt: P04628

Pathways: WNT Signaling, Dopaminergic Neurogenesis