PRTN3 antibody

Catalog No. ABIN969498

This anti-PRTN3 antibody is a Mouse Monoclonal antibody detecting PRTN3 in ELISA. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for PRTN3 antibody (ABIN969498)

Target: PRTN3 (Proteinase 3 (PRTN3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRTN3 antibody is un-conjugated

Application: ELISA

Clone: 3B4

Product Details anti-PRTN3 Antibody

Purpose: Proteinase 3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PRTN3 antibody (ABIN969498)

Kantari, Pederzoli-Ribeil, Amir-Moazami, Gausson-Dorey, Moura, Lecomte, Benhamou, Witko-Sarsat: "Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis." in: Blood, Vol. 110, Issue 12, pp. 4086-95, (2007) (PubMed).

Abdgawad, Hellmark, Gunnarsson, Westman, Segelmark: "Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism." in: Clinical and experimental immunology, Vol. 145, Issue 1, pp. 63-70, (2006) (PubMed).

Target Details for PRTN3

Target: PRTN3 (Proteinase 3 (PRTN3))

Alternative Name: Proteinase 3

Background: Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Molecular Weight: 28 kDa

Gene ID: 5657

UniProt: P24158