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Annexin V Protein expressed in - ABIN412007
Qi, Cooke, Liu, Rimsza, Roe, Persky, Miller, Mahadevan: Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma. in Biochemical pharmacology 2011
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Annexin V Protein expressed in - ABIN412015
Corcoran, Contino, Deshpande, Tzatsos, Conrad, Benes, Levy, Settleman, Engelman, Bardeesy: STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. in Cancer research 2011
Show all 16 Pubmed References
Annexin V Protein expressed in - ABIN412009
Breckenridge, Nguyen, Kuppig, Reth, Shore: The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Annexin V Protein expressed in Escherichia coli (E. coli) - ABIN413009
Xin, Herrmann, Reckamp, Zhang, Pal, Hedvat, Zhang, Liang, Scuto, Weng, Morosini, Cao, Zinda, Figlin, Huszar, Jove, Yu: Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. in Cancer research 2011
Show all 11 Pubmed References
Annexin V Protein expressed in - ABIN412017
Banerjee, Feuer, Barker et al.: Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous ... in Journal of virology 2007
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Annexin V Protein expressed in - ABIN412013
Campbell, Bhat-Nakshatri, Patel, Constantinidou, Ali, Nakshatri: Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. in The Journal of biological chemistry 2001
Show all 8 Pubmed References
Human Annexin V Protein expressed in Escherichia coli (E. coli) - ABIN2690962
Martin, Reutelingsperger, McGahon, Rader, van Schie, LaFace, Green: Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. in The Journal of experimental medicine 1995
Show all 6 Pubmed References
Human Annexin V Protein expressed in Escherichia coli (E. coli) - ABIN2746063
Bhat, Oberg, Kabelitz: Modulation of human gamma/delta T-cell activation and phenotype by histone deacetylase inhibitors. in Cellular immunology 2015
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Chemical Annexin V Protein expressed in Escherichia coli (E. coli) - ABIN2688832
Andree, Reutelingsperger, Hauptmann, Hemker, Hermens, Willems: Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers. in The Journal of biological chemistry 1990
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Human Annexin V Protein expressed in Escherichia coli (E. coli) - ABIN2746059
Nguyen, Hamzeh-Cognasse, Palle, Anselme-Bertrand, Arthaud, Chavarin, Pozzetto, Garraud, Cognasse: Role of Siglec-7 in apoptosis in human platelets. in PLoS ONE 2014
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This study confirmed the proposed role of M2/ANXA5 as embryonic, genetically associated thrombophilia predisposition factor for early recurrent pregnancy loss among ethnic Malay of Malaysia.
Circulating anxA5 levels are associated with carotid intima-media thickness but not coronary plaque composition in high-risk patients with diabetes mellitus.
Results showed that ANXA5 rs1050606 was significantly associated with left ventricular hypertrophy in Chinese endogenous hypertension patients.
Moreover, mechanism study exhibited that Annexin A5 could activate PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway, promote epithelial-mesenchymal transition (EMT (show ITK Proteins)) and the expression of MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins). Annexin A5 may be a potential prognostic biomarker in RCC (show XRCC1 Proteins) and promotes proliferation, migration and invasion of RCC (show XRCC1 Proteins) cells via activating PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway and regulating EMT (show ITK Proteins) process and MMP expression.
human myotubes rendered deficient for Annexin-A5 (AnxA5) suffer from a severe defect in membrane resealing.
This study functionally characterized allelic variants in the ANXA5 promoter, both alone and in combinations, and the results suggest that combinations of several individual variants contribute to modulate the ANXA5 transcriptional activity, most likely through binding of nuclear factors.
Chronically increased alveolar annexin V levels, as reflected in increased idiopathic pulmonary fibrosis (IPF) BALF levels, may contribute to the progression of IPF by inducing the release of pro-fibrotic mediators.
lower exhaled breath condensate annexin A5 levels in children with exercise-induced asthma compared to non-exercised-induced one
annexin A5 promoter haplotype M2 may not have a role in recurrent pregnancy loss in Estonia or Denmark
Annexin V is fused to an enzyme, creating a fusion protein that converts nontoxic drug precursors, prodrugs, into anticancer compounds while bound to the tumor, therefore mitigating the risk of side effects.
Eight-week-old ApoE-/-mice were fed a western diet while being administered AnxA5 or control (M1234) for a total of 6 weeks. AnxA5 administration reduced plaque size in the aortic root as well as the aortic arch by 36% and 55% respectively
Anxa5 mediates the in vitro malignant behaviours of murine hepatocarcinoma Hca-F cells via ERK2 (show MAPK1 Proteins)/c-Jun (show JUN Proteins)/p-c-Jun (show JUN Proteins)(Ser73) and ERK2 (show MAPK1 Proteins)/E-cadherin (show CDH1 Proteins) pathways.
findings suggest that GnRH (show GNRH1 Proteins) is necessary for constitutive ANXA5 expression in the pituitary gland, not only in gonadotropes but also in other pituitary gland cell types
As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice.
These data suggest that AnxA2 (show ANXA2 Proteins) and AnxA5 can influence bone formation via regulation of osteoprogenitor proliferation, differentiation, and responsiveness to cytokines in addition to their well-studied function in matrix vesicles
annexin A5 may play a crucial role in cisplatin-induced toxicity by mediating the mitochondrial apoptotic pathway via the induction and oligomerization of VDAC.
The decrease of miR-1 and increase of AnxA5 appear as important modulators of NCX1 (show SLC8A1 Proteins) expression and activity during heart failure.
double and opposite role of annexin A5 in regulating the endocytic and autophagic pathways and the fusion of autophagosomes with lysosomes and endosomes
Hence, the presence of maternal Anxa5 minimises the risk of thrombosis in the placental circulation and reduces the risk of foetal loss.
inhibited efferocytosis with annexin V worsened elastase-induced pulmonary emphysema in mice, which was, at least partly, attributed to a lack of phenotypic change in macrophages toward anti-inflammatory one.
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
, annexin A5
, Annexin A5
, annexin A5-like
, anchorin CII
, annexin V
, calphobindin I
, endonexin II
, lipocortin V
, placental anticoagulant protein 4
, placental anticoagulant protein I
, thromboplastin inhibitor
, vascular anticoagulant-alpha
, Annexin V
, annexin V (endonexin II)